The Tuesday opinion from the 6th U.S. District Court of Appeals panel stems from a law signed in 2004 by then-Gov. Bob Taft.
The legislation banned the use of RU-486, or mifepristone, to induce abortion unless prescribed by a doctor in compliance with U.S. Food and Drug Administration guidelines.
Three Planned Parenthoods and some private practitioners sued over the law, arguing that it infringed on a woman's right to choose and is constitutionally vague.
Last year, U.S. District Judge Susan Dlott ruled against the abortion providers and said the law didn't create a substantial obstacle to a woman's right to choose.