The crash occurred around 1 p.m. Friday.
A Northwood couple was traveling southbound on Ohio 51 in a Ford pickup truck. The driver of the truck started to cough up blood, causing him to swerve into the other lane, according to Sgt. Eric Short of the Ohio State Highway Patrol.
The truck crashed into the Toledo man's oncoming 2005 Chevy.
The driver of the Chevy was ejected from the driver's side of his car and became trapped under his own car where he was pronounced dead at the scene.