An Erie County grand jury returned an indictment against Tre'Vonte Adcock, 18, Friday.
Adcock is accused of stabbing Jared Rhodes, 24, when the two were at a home in the 1300 block of Clinton St. at about 3 a.m. Dec. 15.
Family members said the two frequently played around and wrestled.
Adcock later told police he had simply poked his uncle with a 4-inch knife.
When police answered a 911 call to the Clinton Street home, they found Rhodes in a pool of blood and Adcock yelling profanities and trying to move Rhodes' body.
He died at the hospital about 11 hours later.
Police initially arrested Adcock for misconduct at an emergency, and prosecutors later filed a murder charge against him.
He is held at the Erie County jail on a $1 million bond.