A Columbus police report said it happened Wednesday afternoon on the east side of the city. A 19-year-old man who lives at the home with his mother and sister told officers he heard noises in an upstairs bedroom.
He got a handgun and went to investigate. He fired at the intruder, who fell out of the window to a concrete patio below.
It wasn't clear whether he died from the gunshot or the fall. His name was not released.
The resident was not charged, but police say the investigation is continuing and will be referred to the county prosecutor's office for a determination.